Description
Description:
Metolazone (Royalty) is a white to off-white, crystalline powder that is sparingly soluble in water and alcohol. It functions as a potent diuretic by inhibiting sodium and chloride reabsorption in the distal tubules of the kidney, leading to increased excretion of water, sodium, chloride, and potassium. It is typically administered orally in tablet form.
Key Features:
- Therapeutic Use: Management of hypertension and edema.
- Mechanism of Action: Thiazide-like effect on distal renal tubules, promoting diuresis.
- Dosage Forms: Oral tablets (as prescribed).
- Advantages: Effective in patients who are resistant to other diuretics and in cases requiring long-term blood pressure control.
Precautions:
- May cause electrolyte imbalances such as hypokalemia or hyponatremia.
- Monitor blood pressure, kidney function, and electrolyte levels regularly.
- Use with caution in patients with gout, diabetes, or impaired renal function.
- Avoid excessive dehydration and orthostatic hypotension.
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